Protective Effect and Mechanism of Placenta Extract on Liver

Placenta extract (PE) shows significant potential in protecting and improving liver health by offering antioxidative, anti-inflammatory, and anti-apoptotic effects. It reduces oxidative stress, inflammation, and apoptosis, while promoting liver regeneration and improving liver morphology and function. PE achieves this by reducing collagen deposition, lipogenesis, and inflammatory cell infiltration, and by inhibiting fibrosis-related proteins and enhancing liver regeneration markers. It also activates the Nrf2 pathway, decreases macrophage accumulation, and regulates autophagy. Despite its promise in treating liver diseases like hepatitis, liver fibrosis, and fatty liver, further systematic research is needed to fully understand its therapeutic potential.