Prostaglandin-Associated Periorbitopathy: Case Report and Basic Pathophysiological Reminder

    January 2014 in “ Turkish Journal of Ophthalmology ”
    Murat Küçükevcilioğlu, Atilla Bayer
    TLDR Prostaglandin treatments for glaucoma can cause rare eye area changes like eyelid deepening and fat pad prolapse.
    Prostaglandin analogues such as latanoprost and travoprost, along with the prostamide bimatoprost, were commonly used in glaucoma treatment due to their effectiveness in lowering intraocular pressure. Known side effects included trichomegaly, increased periocular pigmentation, and adnexal hair growth. However, a rare side effect termed prostaglandin-associated periorbitopathy was identified, characterized by changes such as deepening of the upper lid sulcus, ptosis, enophthalmus, regression in dermatochalasis, and lower lid lateral orbital fat pad prolapsus. This case report highlighted this uncommon side effect in three glaucoma patients treated with bimatoprost and travoprost, emphasizing the need to consider these potential changes in clinical practice.
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      community Why not Travopost? More effective than min, and stackable.

      in Research/Science  18 upvotes 11 months ago
      Travoprost may be more effective than minoxidil for hair growth and can be used alongside it, but its effectiveness is debated due to inconsistent dosing results. Travoprost is expensive and not widely used, with alternatives like latanoprost and bimatoprost being more accessible.

      community Painkillers May Block Minoxidil

      in Research/Science  14 upvotes 8 months ago
      Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  55 upvotes 8 months ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

      community Min/Fin topical prescription also contains Latanoprost?

      in Treatment  3 upvotes 11 months ago
      A user discusses a topical prescription for hair regrowth containing Minoxidil, Finasteride, and Latanoprost, noting Latanoprost's side effect of promoting eyelash and eyebrow growth. Others share experiences and information about Latanoprost, highlighting its origins as a glaucoma drug and potential side effects.

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