Promotive Effect of Minoxidil Combined with All-trans Retinoic Acid (tretinoin) on Human Hair Growth in Vitro

    April 2007 in “Journal of Korean Medical Science
    Oh Joon Kwon, Hyun-Mi Pyo, Youn-Jin Oh, Ji Won Han, Se Rah Lee, Jin Wook Chung, Hee Chul Eun, Se Kyu Kim
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    TLDR Minoxidil and ATRA together boost hair growth more effectively than minoxidil alone.
    A study from 16 years ago found that combining minoxidil and all-trans retinoic acid (ATRA) increased hair growth in vitro more than minoxidil alone. The combination also increased the expression of proteins related to hair growth, suggesting it could be a promising treatment for hair loss. The combination treatment enhanced hair growth more efficiently than minoxidil alone by increasing the proliferation of human dermal papilla cells and prolonging the anagen stage of hair growth. The study suggests that the combination of minoxidil and ATRA could be a potential treatment for hair loss.
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