Smooth Muscle Cell Expression of a Constitutively Active Form of Human Profilin1 Accelerates Cutaneous Wound Repair

The study investigated the role of profilin1 in wound healing using profilin1 and 88R/L transgenic mice. It was found that profilin1 significantly accelerated wound closure, with wound size reductions of 52%, 25%, and 17% at post wound days 3, 6, and 9, respectively, compared to nontransgenic and 88R/L mice. Profilin1 mice also showed increased vascularization, cell migration, hair follicle formation, and expression of collagen IV and VEGF. Western blot analyses revealed significant increases in collagen III, integrins, SRF, Rac1, and HIF1α in the wound area of profilin1 mice. The study concluded that profilin1 played a crucial role in wound closure.