Smooth Muscle Cell Expression of a Constitutively Active Form of Human Profilin1 Accelerates Cutaneous Wound Repair

    April 2011 in “ The FASEB Journal ”
    Zeinb A. Abouelnaga, Mohamed D.H. Hassona, Mohammad T. Elnakish, Mazin Alhaj, Hamdy H. Hassanain
    TLDR Profilin1 speeds up wound healing.
    The study investigated the role of profilin1 in wound healing using profilin1 and 88R/L transgenic mice. It was found that profilin1 significantly accelerated wound closure, with wound size reductions of 52%, 25%, and 17% at post wound days 3, 6, and 9, respectively, compared to nontransgenic and 88R/L mice. Profilin1 mice also showed increased vascularization, cell migration, hair follicle formation, and expression of collagen IV and VEGF. Western blot analyses revealed significant increases in collagen III, integrins, SRF, Rac1, and HIF1α in the wound area of profilin1 mice. The study concluded that profilin1 played a crucial role in wound closure.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 21 results

      community What else is good. Besides the big 3.

      in Chat  35 upvotes 1 year ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community Vitamin C and hair growth PH levels

      in Product  36 upvotes 4 years ago
      The conversation is about using vitamin C and Magnesium L-Threonate for hair growth by reducing DHT binding to dermal papilla cells. The original post about vitamin C's pH levels and sebum control was possibly removed by a moderator.

      community Results of Procyanidin B2 in clinical studies

      in Treatment  13 upvotes 5 years ago
      Procyanidin B2, a compound derived from Annurca apples, as a potential treatment for pattern hair loss. Several clinical studies were mentioned, which found that procyanidin B2 could increase hair growth, density, and keratin content. Other treatments such as Minoxidil, Finasteride, and RU58841 were not discussed.

      community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

      in Research/Science  12 upvotes 1 year ago
      A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.

    Related Research

    2 / 2 results