Dynamics of Procollagen Type 1 N-Terminal Propeptide in Postmenopausal Osteoporosis During Bisphosphonate Therapy and Transcranial Electrical Stimulation

The study investigated the effect of transcranial electrical stimulation on procollagen type I N-terminal propeptide (P1NP) levels in 48 postmenopausal osteoporosis patients undergoing bisphosphonate therapy. Over 12 months, 25 patients received only bisphosphonates (group 1), while 23 patients received additional transcranial electrical stimulation (group 2). Initially, no differences in P1NP levels were observed between the groups. After 12 months, group 2 showed a 12.1% higher P1NP level compared to group 1, where P1NP decreased by 11.0%. The findings suggest that transcranial electrical stimulation combined with bisphosphonates has a protective effect on bone collagen biosynthesis, as evidenced by the maintained P1NP levels in group 2.