Pride Syndrome With Lumbosacral Hypertrichosis

The document described a case of an 80-year-old man with PRIDE syndrome, a cutaneous adverse effect of EGFR inhibitors, who presented with lumbosacral hypertrichosis. The patient, treated with gefitinib for lung squamous cell carcinoma, exhibited symptoms including itchy papules, xerosis, and paronychia. The study highlighted that while hair changes were rare in PRIDE syndrome, this case was notable for the unusual site of hypertrichosis. The findings suggested that EGFR inhibitors might cause localized hair growth abnormalities, emphasizing the need for thorough examinations to identify atypical adverse effects.