Pride Syndrome With Lumbosacral Hypertrichosis

January 2022 in “ Dermatology Review ”

Saima Naaz, Hania Khan, Syed Suhail Amin, Shriya Kaushik, Shagufta Qadri

PRIDE syndrome lumbosacral hypertrichosis EGFR inhibitors gefitinib xerosis paronychia

Studysummary This case report details an occurrence of PRIDE syndrome accompanied by lumbosacral hypertrichosis.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document described a case of an 80-year-old man with PRIDE syndrome, a cutaneous adverse effect of EGFR inhibitors, who presented with lumbosacral hypertrichosis. The patient, treated with gefitinib for lung squamous cell carcinoma, exhibited symptoms including itchy papules, xerosis, and paronychia. The study highlighted that while hair changes were rare in PRIDE syndrome, this case was notable for the unusual site of hypertrichosis. The findings suggested that EGFR inhibitors might cause localized hair growth abnormalities, emphasizing the need for thorough examinations to identify atypical adverse effects.

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