Prepubertal Pattern Hair Loss

The document discusses a condition termed "prepubertal pattern hair loss" (PHL), which is characterized by hair thinning and widening of the central parting of the scalp in children under the age of 10, resembling female pattern hair loss (FPHL). A retrospective chart review at a referral center identified 74 cases (59 female and 15 male) with this condition, none of whom had premature puberty or endocrinological abnormalities. A strong family history of androgenetic alopecia (AGA) was noted in many cases. The condition responded to treatment with topical minoxidil at a reduced dosage for children. The findings suggest that FPHL may not be androgen-dependent, as it occurs in prepubertal children without the influence of androgens. The incidence and prevalence of AGA in the pediatric population are not well-known, and further research is needed, although laboratory evaluations are only recommended if PHL is associated with signs of premature puberty or presents with male pattern hair loss (MPHL).