Pregnancy and Neonatal Outcome with Maternal Exposure to Finasteride: Case Series

July 2021 in “ Journal of Dermatology and Dermatologic Surgery ”

HessahF BinJadeed, Abdulmajeed Alajlan

finasteride teratogenic medications genital anomalies in utero exposure Propecia

Studysummary This study observed that male fetuses exposed to finasteride in utero may develop external genital anomalies, with the outcome dependent on the timing of exposure.

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research The Efficacy and Use of Finasteride in Women: A Systematic Review

23 citations , January 2019 in “International Journal of Dermatology”

This review found that while finasteride may improve female pattern hair loss and hirsutism in women, more long-term studies are needed to optimize its use and assess potential consequences.

research Finasteride Use During Pregnancy and Early Neonatal Outcome: A Case Report

3 citations , June 2018 in “International Journal of Clinical Pharmacy”

In this case report, maternal use of finasteride during early pregnancy was not associated with external genitalia abnormalities in a male infant, but the findings are limited to one case and broader safety conclusions cannot be drawn.

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version

145 citations , November 2017 in “Journal of The European Academy of Dermatology and Venereology”

This guideline review by the European Dermatology Forum evaluates current treatments for androgenetic alopecia but reports no new research findings, aiming to assist dermatologists in selecting safe and effective therapies.

research The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis

178 citations , April 2017 in “Journal of The American Academy of Dermatology”

This systematic review and meta-analysis found that minoxidil, finasteride, and low-level laser light therapy significantly improve hair growth in men with androgenetic alopecia, while minoxidil is also effective for women, compared to placebo.

research Androgenetic Alopecia: An Update Of Treatment Options

110 citations , August 2016 in “Drugs”

Minoxidil is the only FDA-approved topical drug for treating male or female pattern hair loss, and other medications like finasteride and dutasteride can also increase hair growth.

research Aphalangia Possibly Linked to Unintended Use of Finasteride During Early Pregnancy

6 citations , March 2009 in “Annals of Saudi Medicine”

Finasteride use during early pregnancy may cause limb deformities in babies.

research Effects of In Utero Exposure to Finasteride on Androgen-Dependent Reproductive Development in Male Rats

118 citations , May 2003 in “Toxicological Sciences”

This study found that prenatal exposure to finasteride in rats led to permanent changes in developmental endpoints like anogenital distance and nipple retention, which were predictive of further reproductive tract malformations.

research Finasteride

125 citations , January 1999 in “Drugs”

This study found that oral finasteride 1 mg/day promotes hair growth and prevents further hair loss in a significant proportion of men with male pattern hair loss over two years.

research External Genitalia Abnormalities in Male Rats Exposed In Utero to Finasteride, a 5α-Reductase Inhibitor

122 citations , July 1990 in “Teratology”

This study found that oral administration of finasteride to pregnant rats caused dosage-related developmental toxicities, including hypospadias and decreased anogenital distance in male offspring.