Evaluating the Efficacy and Safety of Combined Microneedling Therapy vs. Topical Minoxidil in Androgenetic Alopecia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
January 2026
in “
British Journal of Dermatology
”
New to Minoxidil? There is a guide in the encyclopedia. Read the guide → Studysummary This study found that combined microneedling with minoxidil significantly improved hair count and diameter in patients with androgenetic alopecia compared to minoxidil alone, despite mild adverse events, and microneedling parameters like depth and duration did not significantly affect outcomes.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This systematic review and meta-analysis evaluated the efficacy and safety of combined microneedling therapy (CMNT) with minoxidil compared to minoxidil alone in treating androgenetic alopecia (AGA). The study included 12 randomized controlled trials with 631 patients. Results showed that CMNT significantly improved hair count and diameter compared to minoxidil monotherapy, with a standardized mean difference of 1.32 for hair count and 0.34 for hair diameter. The microneedling parameters such as depth, duration, and technique did not significantly impact the outcomes. Although adverse events were more frequent with CMNT, they were generally mild. Overall, CMNT is a promising adjunctive treatment for AGA.
