The Potential of Fibroblast Growth Factors to Stimulate Hair Growth In Vitro

    January 2021
    George Cheng, Venka Subramani, Halle Lutz
    Image of study
    TLDR Some fibroblast growth factors may promote hair growth similarly to minoxidil and could potentially treat hair loss.
    The study from 2021 investigated the potential of fibroblast growth factors (FGFs) as an alternative to minoxidil for treating androgenic alopecia (AGA), a common form of hair loss. Four types of FGFs (FGF1, FGF2, FGF10, and FGF21) were tested on isolated primary mouse hair follicle dermal papilla (DP) cells, and compared to minoxidil. The results showed that several FGFs promoted DP cell proliferation, similar to minoxidil, even in the absence of a vascular system. Additionally, DP cells cultured in FGFs exhibited a more organized cytoskeleton compared to those cultured with minoxidil, indicating potential benefits of FGFs for cellular health. The researchers hypothesized that FGFs could stimulate hair growth and treat AGA.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 24 results

      community Comprehensive Microneedling Guide

      in Microneedling  291 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.
      [object Object]
      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      in Research  759 upvotes 3 months ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

      community Verteporfin and Microneedling

      in Treatments 7 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

    Related Research

    2 / 2 results