Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan

    June 2010 in “BMC Medicine
    Helena Teede, Amanda Deeks, Lisa J. Moran
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    TLDR Polycystic ovary syndrome is a complex condition that affects women's mental, reproductive, and metabolic health throughout their lives.
    The 2010 review by Teede et al. addresses Polycystic ovary syndrome (PCOS), affecting up to 20% of women of reproductive age, with significant health implications throughout their lifespan. PCOS is linked to insulin resistance, hyperandrogenism, and an increased risk of metabolic syndrome, prediabetes, and type 2 diabetes, especially in overweight women. The review highlights the importance of a multidisciplinary approach to treatment, including lifestyle interventions for weight management and normalization of insulin resistance, which can significantly improve PCOS symptoms with even modest weight loss. Pharmacological treatments such as oral contraceptive pills and Metformin are also discussed, with the latter improving clinical features and having cardiometabolic benefits, though not inducing weight loss. The review calls for comprehensive guidelines for early diagnosis and treatment, emphasizing the need for greater attention to the cardiometabolic and psychological aspects of PCOS, alongside the reproductive issues. Further research is needed for this complex condition to develop evidence-based management strategies.
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    Cited in this study


      Polycystic Ovary Syndrome (PCOS) and Fertility

      research Polycystic Ovary Syndrome (PCOS) and Fertility

       20 citations,  January 2016 in “Open Journal of Endocrine and Metabolic Diseases”
      PCOS affects fertility and is linked to obesity and menstrual irregularities; lifestyle changes are recommended for treatment.


       2 citations,  January 1970 in “Asian journal of pharmaceutical research and development”
      PCOS is a hormonal disorder affecting many women, leading to symptoms like acne and irregular periods, and increasing the risk of diabetes and heart disease.