PNU 157706, a novel dual type I and II5α-reductase inhibitor
February 1998
in “The Journal of Steroid Biochemistry and Molecular Biology”
TLDR PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.
PNU 157706 was identified as a potent inhibitor of both type I and II 5α-reductase enzymes, surpassing the efficacy of finasteride, a known inhibitor. It demonstrated IC50 values of 3.9 nM for type I and 1.8 nM for type II 5α-reductase in human recombinant enzymes. In vivo studies showed that PNU 157706 reduced prostatic DHT levels more effectively than finasteride in rats, without binding to the androgen receptor, indicating no anti-androgen activity. The compound also significantly reduced prostate weight in castrated rats implanted with testosterone, but not in those implanted with DHT, suggesting its action is specific to inhibiting 5α-reductase. These results suggest PNU 157706 could be a more efficient therapy for conditions related to DHT, such as benign prostatic hyperplasia and androgenic alopecia.
View this study on doi.org →
Cited in this study
research Effect of MK-386, a novel inhibitor of type 1 5 alpha-reductase, alone and in combination with finasteride, on serum dihydrotestosterone concentrations in men
research FCE 28260, a new 5α-reductase inhibitor: In vitro and in vivo effects
FCE 28260 is a stronger and longer-lasting inhibitor of 5α-reductase than finasteride, which may make it a better treatment for certain medical conditions.
research 5α‐Reductase inhibitors and prostatic disease
5α-Reductase inhibitors can help treat hair loss, acne, and prostate issues by reducing DHT levels.
research Finasteride
Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.
research LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1.
LY191704 is a compound that effectively blocks a specific enzyme involved in hormone conversion and could help treat enlarged prostate and hair loss.
research The Effect of Finasteride in Men with Benign Prostatic Hyperplasia
Finasteride effectively treats BPH but may increase sexual dysfunction risk.
research Species Differences in Prostatic Steroid 5α-Reductases of Rat, Dog, and Human
Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.
Related
research Effect of finasteride, a 5 alpha-reductase inhibitor, on serum gonadotropins in normal men.
Finasteride doesn't affect hormone levels in normal men.