The Journey of Platelet Concentrates: An Era of Regeneration in Medicine and Dentistry - A Review

Platelet concentrates (PC), including PRP, PRGF, and PRF, have become valuable in promoting tissue regeneration across various medical and dental fields. They are effective in managing hemostasis, vascular integrity, and releasing growth factors for tissue repair. The review highlights their applications in sports medicine, orthopedics, maxillofacial surgeries, periodontal and bone defect treatments, and androgenetic alopecia. It emphasizes the advantages of using PCs, particularly the second-generation L-PRF, due to its autologous nature, ease of preparation, and consistent results. L-PRF has improved outcomes in surgical periodontal therapy, bone grafting, implant surgery, diabetic foot ulcers, tendon remodeling, alopecia, and osteoarthritis. A study by Pradeep AR is mentioned, comparing autologous PRF with PRF combined with Hydroxyapatite in treating intrabony defects. Despite their benefits, limitations include low yield, handling difficulties, and the antigenic nature of PRF membranes, which prevents their use as allogenic graft tissue.