Thirty Years of Autologous Platelet Concentrates: From Platelet-Rich Plasma to Platelet-Rich Fibrin

    August 2025 in “ Journal of Periodontal Research ”
    Richard J. Miron, Nathan E. Estrin, Paras Ahmad, Nima Farshidfar, Masako Fujioka‐Kobayashi, Yufeng Zhang, Mario Romandini, Reinhard Gruber
    Over the past 30 years, autologous platelet concentrates (APCs) like platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) have been developed to enhance healing by concentrating growth factors and cells. PRF, which eliminates anti-coagulants, has shown superior natural healing benefits, particularly in dentistry for procedures such as periodontal regeneration and sinus grafting. Beyond dental applications, PRF is effective in treating diabetic ulcers, joint pain, and in esthetic medicine. Recent advancements include horizontal centrifugation techniques and the development of extended-PRF (e-PRF) membranes, which extend membrane degradation up to 4 months, offering a new alternative to collagen membranes in dental procedures.
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