Pharmacokinetic Study in Hairless Rat After Topical Application of Finasteride: Single and Repeated Dose

January 2012 in “ Journal of Investigative Dermatology ”

F. Mailland, Silvia Tampucci, Susi Burgalassi, Patrizia Chetoni, Maurizio Caserini, Daniela Monti

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community [study analysis] Microdose of topical Finasteride for all the benefits and none of the sides?

in Research/Science 104 upvotes 5 years ago

Topical finasteride as a potential alternative to oral finasteride for reducing DHT levels on the scalp with fewer side effects, and other hair loss treatments such as minoxidil.

community Blood results on micro-dosing topical finasteride (DHT Increased!)

in Finasteride/Dutasteride 6 upvotes 3 years ago

The conversation discusses using homemade topical finasteride for hair loss, showing an increase in DHT levels despite treatment. The user applies 0.125mg daily, resulting in 113.4% of previous DHT levels.

community Phase II topical dut study - outperforms oral fin with a minor DHT reduction

in Research/Science 61 upvotes 1 month ago

Topical dutasteride 0.05% is more effective for hair growth than oral finasteride 1mg, with minimal DHT reduction. The formulation uses castor oil and MCTs for better absorption but is not widely available until 2028.

community If half life of fin is 6-8 hours in the blood but 5-6 days in tissue (scalp) why don't people apply topical every 3-4 days to minimize systemic?

in Treatment 28 upvotes 2 years ago

The discussion revolves around the frequency of applying topical finasteride for hair loss treatment. The main question is whether applying it every 4-5 days could still be effective, given that its half-life in the scalp tissue is 5-6 days.

community A Nuanced Look at Microdosing Topical Finasteride

in Finasteride/Dutasteride 86 upvotes 2 years ago

The conversation discusses using a low dose of topical finasteride to achieve hair benefits with minimal systemic exposure. Users share experiences and opinions on dosing, systemic buildup, and side effects of both topical and oral finasteride.

community Topical finasteride (P-3074) inhibits scalp DHT up to 70%

in Finasteride/Dutasteride 20 upvotes 1 month ago

Topical finasteride (P-3074) can inhibit scalp DHT by up to 70%, with some users experiencing systemic absorption similar to oral use. Users discuss varying application frequencies and concentrations, with some noticing side effects when overused.