Pharmacology of Topical Finasteride Formulations in Rats

January 2018

สุธีรา ภูมิภักดี

finasteride topical formulation pharmacokinetics plasma levels skin-to-blood ratio dermis systemic absorption Propecia

TLDR Topical finasteride accumulates in the skin with minimal absorption into the bloodstream.

This study investigated the pharmacokinetics of a 0.5% finasteride topical formulation in male Sprague-Dawley rats. It aimed to measure finasteride levels in plasma and skin after single and repeated applications. Results showed that finasteride was minimally absorbed into the bloodstream, with detectable plasma levels only after a single application of 300 µl. Repeated applications (1 or 2 times daily for 7 days) did not significantly affect plasma levels. The skin-to-blood ratio was approximately 2.6, indicating that finasteride remained primarily in the dermis. The study suggests that topical finasteride has limited systemic absorption and may not cause significant systemic effects.

View this study on cuir.car.chula.ac.th →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 41 upvotes 5 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community With studies showing that 0.2mg Finasteride is almost as effective as 5mg at reducing DHT, why is every doctor prescribing 1mg?

in Finasteride/Dutasteride 243 upvotes 1 week ago

Finasteride is prescribed at 1mg because it is FDA-approved and proven effective, despite evidence that 0.2mg may similarly reduce DHT. The 1mg dose is more effective for hair growth, and lower doses are less available.

community The New, Improved CB-03-01/Setipiprant Group Buy

27 upvotes 9 years ago

The group buy for CB-03-01, a topical anti-androgen for hair loss, was postponed and refunded due to issues with the product's form and solubility. The product, also known as Breezula, is an alternative to finasteride with fewer side effects, but its official release is delayed until 2021.

community Sublingual Minoxidil - Cure to Hairloss?

in Minoxidil 583 upvotes 2 years ago

The conversation discusses the potential benefits of sublingual minoxidil for hair loss treatment. It suggests that sublingual minoxidil, which bypasses the liver, may have fewer side effects, greater bioavailability, and could be more effective than oral minoxidil.

community 15 Week Update of Oral Consumption of Topical Minoxidil. 3 drops Keeps 5% (3.75mg) 2x per day with comparison.

in Update 3 years ago

CumShotDiva's update on using topical minoxidil orally in an attempt to regrow hair, which has been met with both support and criticism from other users. The conversation includes discussion of possible side effects and the efficacy of this approach.

community MY 6 MONTH TRANSFORMATION PROGRESS

in Progress Pictures 210 upvotes 1 year ago

A 23-year-old male shared his 6-month hair transformation using Dutasteride, oral Minoxidil, ketoconazole shampoo, vitamin D, gym, cardio, and dermastamping. He reported significant hair maintenance and no side effects.

Related Research

3 / 3 results

research Change in Hair Growth-Related Gene Expression Profile in Human Isolated Hair Follicles Induced by 5-Alpha Reductase Inhibitors – Dutasteride and Finasteride – in the Presence of Testosterone

1 citations , June 2021 in “Singapore Medical Journal”

Dutasteride and finasteride can help increase hair growth gene expression but need further improvement.

research 5 Alpha-Reductase and Finasteride in Pattern Alopecia and Acne

2 citations , December 2004 in “PubMed”

research 5-Alpha-Reductase Inhibitors/Finasteride

4 citations , January 1996 in “PubMed”