Phamacopuncture and Dermal Application of Sebalgukhwa-san: Effects on Hair Growth in a Mouse Model of Alopecia
May 2019
in “Journal of Acupuncture Research”
TLDR Sebalgukhwa-san (SGS) can help treat hair loss without liver toxicity.
The study evaluated the effects of pharmacopuncture and dermal application of Sebalgukhwa-san (SGS) extracts on hair growth in an alopecia mouse model using 21 C57BL/6 mice. Results showed that both minoxidil (MNXD) and SGS treatments significantly improved hair growth, density, and thickness compared to the control group (p < 0.05). The number of hair follicles increased, although their size did not change. Protein expression related to hair growth showed increased levels of vascular endothelial growth factor and insulin-like growth factor-1, and decreased transforming growth factor-beta 1, but these changes were not statistically significant. SGS treatment did not exhibit liver toxicity. The study concluded that SGS could be beneficial for treating alopecia.
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