Cutaneous Manifestations of Polycystic Ovary Syndrome
December 2025
in “
BENTHAM SCIENCE PUBLISHERS eBooks
”
Studysummary This review discusses the interplay between endocrinology and dermatology in PCOS, highlighting the roles of hyperandrogenism, insulin resistance, and chronic inflammation in related skin conditions, but reports no new clinical results.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The document discusses the dermatological issues associated with Polycystic Ovary Syndrome (PCOS), such as hirsutism, acne, androgenetic alopecia, and acanthosis nigricans, which significantly affect patients' well-being. It emphasizes the importance of understanding the pathophysiological mechanisms for early detection and management. Key factors include hyperandrogenism, insulin resistance, and chronic inflammation, influenced by immunological pathways, genetic predispositions, and hormonal imbalances. Hirsutism is linked to androgen excess and increased 5α-reductase activity, while adult acne is exacerbated by androgens and chronic inflammation. Androgenetic alopecia involves Wnt signaling alterations and scalp inflammation. Acanthosis nigricans, associated with insulin resistance, underscores metabolic dysfunction in PCOS, driven by insulin-like growth factor receptor abnormalities and hyperinsulinemia. The chapter highlights the complex interplay between endocrinology and dermatology in PCOS.
