Cutaneous Manifestations of Polycystic Ovary Syndrome

    December 2025 in “ BENTHAM SCIENCE PUBLISHERS eBooks ”
    Vishal Gaurav
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    TLDR PCOS often causes skin issues like excess hair, acne, hair thinning, and dark patches due to hormone imbalances and insulin resistance.
    The document discusses the dermatological issues associated with Polycystic Ovary Syndrome (PCOS), such as hirsutism, acne, androgenetic alopecia, and acanthosis nigricans, which significantly affect patients' well-being. It emphasizes the importance of understanding the pathophysiological mechanisms for early detection and management. Key factors include hyperandrogenism, insulin resistance, and chronic inflammation, influenced by immunological pathways, genetic predispositions, and hormonal imbalances. Hirsutism is linked to androgen excess and increased 5α-reductase activity, while adult acne is exacerbated by androgens and chronic inflammation. Androgenetic alopecia involves Wnt signaling alterations and scalp inflammation. Acanthosis nigricans, associated with insulin resistance, underscores metabolic dysfunction in PCOS, driven by insulin-like growth factor receptor abnormalities and hyperinsulinemia. The chapter highlights the complex interplay between endocrinology and dermatology in PCOS.
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