Polycystic Ovarian Syndrome in Patients with Schizophrenia Treated with Atypical Antipsychotics: A Case Control Study

    April 2017 in “ European Psychiatry
    V. De Silva, Anuradha Senanayake, S.S. Ratnatunga, S. A. W. Dissanayake, S. Gamage, S. De Silva, Raveen Hanwella, CN Wijeyaratne
    Image of study
    TLDR Women with schizophrenia on atypical antipsychotics are more likely to have polycystic ovarian syndrome (PCOS) than women without schizophrenia.
    The study aimed to compare the prevalence of probable polycystic ovarian syndrome (PCOS) in females with schizophrenia treated with atypical antipsychotics to that in normal controls. It involved 102 female patients of reproductive age with schizophrenia who had been treated with atypical antipsychotics for at least 6 months and had gained at least 10% body weight, and 123 age and BMI-matched control females. The study found that polycystic ovarian morphology on ultrasound was significantly more common in the cases (48%) than in the controls (13%) (P<0.001). Probable PCOS was also significantly more prevalent in the atypical antipsychotic-treated females (21.56%) compared to the normal controls (8.13%) (P=0.04). The hormonal profile of atypical antipsychotic-treated patients with PCOS showed significantly lower mean LH levels than those without PCOS, but there was no significant difference in testosterone, FSH, prolactin, TSH, and free T4 levels. The conclusion drawn from the study is that treatment with atypical antipsychotics is associated with a higher prevalence of PCOS, and this association had not been reported previously. The study suggests that the hormonal profile in these patients may differ, with low testosterone and LH levels.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 19 results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community PCOS Hair Loss: What’s Helped Me (and What Didn’t)

      in Treatment  8 upvotes 2 weeks ago
      OP shares their experience with PCOS-related hair loss, highlighting that addressing vitamin D and ferritin deficiencies, managing hormones with spironolactone, and using gentle hair care products helped improve their condition. They advise against relying on "miracle" hair oils and emphasize the importance of medical evaluation and a combined approach to treatment.

      community I think this is my stop, gentlepeople. So long and thanks for all the data 👋

      in Transgender  2252 upvotes 2 months ago
      A user shared their successful experience with hair regrowth and transitioning from male to female using minoxidil, finasteride, Nutrafol, microneedling, and hormone replacement therapy (HRT). They expressed gratitude for the results and encouraged others to explore treatments that align with their personal goals.

      community Bryan Johnson just dropped his anti hair loss formula

      in Treatment  339 upvotes 1 year ago
      Bryan Johnson shared his hair loss treatment, which mainly relies on minoxidil and finasteride. Some users are skeptical of his results, while others appreciate his efforts in anti-aging and hair loss research.

    Related Research

    1 / 1 results