TLDR Pili torti hair twists due to uneven outer root sheath cell development.
The study investigated the morphological abnormalities in pili torti, a hair disorder, using various microscopy techniques and 3-D analysis. It found that the hair shafts were partly flattened and twisted, with disruptions occurring at various points. The outer root sheath (ORS) showed irregularities in thickness and cell arrangement, which were linked to the twisting of the hair. The inner root sheath (IRS) also displayed irregularities, contributing to an uneven hair shaft. These findings suggested that unequal development of ORS cells led to the characteristic twisting of hair in pili torti.
36 citations
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January 1987 in “Journal of The American Academy of Dermatology” The document concludes that understanding hair structure is key to diagnosing hair abnormalities and recommends gentle hair care for management.
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July 1984 in “Journal of Investigative Dermatology”
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February 2004 in “British Journal of Dermatology” Keratin in mouse hair follicles is complex and plays specific roles.
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135 citations
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November 1987 in “Differentiation” Outer root sheath cells consistently express certain keratins influenced by their environment.
59 citations
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August 1981 in “PubMed” Trichilemmal keratinization is a unique process in hair follicles where the outer root sheath turns into keratin without a specific layer.
