Paclitaxel-loaded star-shaped copolymer nanoparticles for enhanced malignant melanoma chemotherapy against multidrug resistance

March 2017 in “ Drug Design Development and Therapy ”

Yongsheng Su, Jian Hu, Zhibin Huang, Yubin Huang, Bingsheng Peng, Ni Xie, Hui Liu

paclitaxel cholic acid PLGA-TPGS nanoparticles malignant melanoma multidrug resistance Taxol

TLDR The new nanoparticles could improve melanoma treatment by working better than current options.

The study developed a new nanoformulation of paclitaxel-loaded cholic acid-functionalized star-shaped PLGA-TPGS nanoparticles to enhance chemotherapy for malignant melanoma, which faced challenges like low drug concentration and multidrug resistance. The nanoparticles demonstrated higher cellular uptake efficiency in human melanoma cell line A875 compared to other formulations. In vitro and in vivo tests showed that these nanoparticles had superior antitumor effects compared to the commercial paclitaxel formulation, Taxol®. This suggested that the developed nanoparticles could potentially improve clinical therapy for malignant melanoma.

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