Ozenoxacin Suppresses Sebum Production by Inhibiting mTORC1 Activation in Differentiated Hamster Sebocytes

The study explores the effects of ozenoxacin on sebum production in hamster sebocytes, highlighting its potential as an acne treatment. Ozenoxacin, a topical antibacterial agent, was shown to significantly suppress triglyceride production and lipid droplet formation by inhibiting the mTORC1 signaling pathway. This suppression was dose-dependent, with a maximum inhibition of 115.6% at 10 μmol/L, and it also reduced the expression of genes involved in sebum production. The effects of ozenoxacin were comparable to nadifloxacin, while clindamycin had minimal impact. Importantly, ozenoxacin did not exhibit cytotoxicity and decreased sebum levels in vivo without affecting skin structure, suggesting its dual action in reducing sebum production and microbial proliferation could be beneficial for acne treatment.