TLDR Ozenoxacin reduces sebum production, helping manage acne.
This study investigates the effects of ozenoxacin, a topical quinolone, on sebum production in acne treatment. Using insulin- and 5α-DHT-differentiated hamster sebocytes, ozenoxacin was found to inhibit lipid droplet formation and triacylglycerol production in a dose-dependent manner. It also suppressed the expression of key mRNA involved in sebum synthesis and decreased phosphorylated 40S ribosomal protein S6 levels downstream of mTORC1, without affecting Akt phosphorylation. A 2% ozenoxacin lotion reduced skin surface triacylglycerol in hamsters without altering sebaceous gland size or epidermal thickness. These findings suggest ozenoxacin's potential in controlling sebum production and microbial growth in acne management.
6 citations
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August 2024 in “The Journal of Dermatology” Ozenoxacin reduces sebum production, helping manage acne.
93 citations
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January 2016 in “British Journal of Dermatology” Eating a high-glycemic diet may worsen acne by increasing certain protein levels and expressions in the skin.
74 citations
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October 2015 in “Experimental Dermatology” Acne patients have higher levels of mTOR in their skin, which could be linked to future metabolic disease.
138 citations
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July 2015 in “Clinical, Cosmetic and Investigational Dermatology” Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.
100 citations
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August 2022 in “Microbial Cell Factories” Balancing skin microbiota is crucial for healthy skin and treating skin diseases.
78 citations
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June 2021 in “Dermatology and Therapy” Future acne treatments should aggressively target inflammation to prevent scarring.
August 2018 in “Journal of The American Academy of Dermatology” Ozenoxacin 1% cream is an effective and safe treatment for impetigo in children and adults.
1 citations
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August 2018 in “Journal of The American Academy of Dermatology” Combination of minoxidil and finasteride is more effective in increasing hair diameter than minoxidil alone for female-pattern hair loss.
August 2018 in “Journal of The American Academy of Dermatology” Different treatments for skin conditions were found to be effective and generally safe, with biologics recommended as the first choice for generalized pustular psoriasis.
