The Effect of Oxidized Low-Density Lipoprotein Compared to Cytokine-Induced Inflammation on the Differentiation Properties of Human Gingival Mesenchymal Stem Cells
January 2025
in “
Multimedialen Archiv und Publikationsserver der Christian-Albrechts-Universität zu Kiel (Christian-Albrechts-Universität zu Kiel)
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Studysummary In this study, human gingival mesenchymal stem cells responded differently to inflammation mediated by oxidized low-density lipoprotein (oxLDL) compared to cytokines; oxLDL significantly reduced cell proliferation but had less negative impact on differentiation characteristics.
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This study investigated the effects of oxidized low-density lipoprotein (oxLDL) compared to cytokine-induced inflammation on human gingival mesenchymal stem cells (G-MSCs). Over 7 days, G-MSCs were exposed to a control, cytokine mixture, or oxLDL. Results showed that while initial cell proliferation increased with inflammatory stimuli, cell numbers were highest in the control group after 14 days, followed by the cytokine group, and lowest in the oxLDL group. Osteogenic differentiation was significantly lower in the cytokine group compared to oxLDL, with minor differences in chondrogenic and adipogenic differentiation. G-MSCs responded differently to oxLDL-induced metabolic inflammation than to cytokine-mediated inflammation, showing less negative impact on differentiation but significantly reduced cell proliferation.
