Prospective Outcomes After Serial Platelet-Rich Plasma (PRP) Injection in Vocal Fold Scar and Sulcus

    August 2024 in “ The Laryngoscope ”
    Chloe Santa Maria, Elizabeth A. Shuman, Benjamin van der Woerd, Clare Moffatt, C Castellanos, William Z. Gao, Neel K. Bhatt, Yaël Bensoussan, Jack Rodman, Kacie La Forest, Felicia Francois, Karla O’Dell, Dinesh K. Chhetri, Michael M. Johns
    TLDR PRP injections improve voice quality and are safe for treating vocal fold scars.
    This study investigates the effects of serial platelet-rich plasma (PRP) injections on vocal fold scar and sulcus, conditions that currently lack optimal treatment options. Conducted as a prospective clinical trial across two institutions, 15 patients received a total of 55 PRP injections. The study found that PRP is a safe treatment option, with no adverse effects reported. Results showed a significant improvement in patient-reported outcome measures (PROMs), with an average reduction of 8.7 points in VHI-10 scores and a reduction of 18.8 points in CAPE-V scores. Additionally, 73.4% of cases showed improved voice quality post-treatment, and videostroboscopic assessments indicated enhanced mucosal wave ratings. Despite variability in individual outcomes, the study supports PRP as a promising treatment for vocal fold scarring.
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