TLDR Oral minoxidil improved hair thickness in a person with monilethrix.
The document discusses a case study of a 14-year-old female with monilethrix, a genetic hair disorder characterized by fragile, beaded hair, who developed female androgenetic alopecia (AGA) at age 23. She was successfully treated with 1.25 mg oral minoxidil, which improved hair thickness and diversity of hair shaft diameters, although the structural anomaly of monilethrix persisted. The study highlights that while no specific treatment exists for monilethrix, minoxidil can be beneficial for comorbid AGA, enhancing hair length and thickness. The report emphasizes the importance of recognizing multiple causal relationships in hair disorders and the advantage of oral minoxidil in reducing trauma to fragile hair compared to topical applications.
37 citations
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May 2016 in “JAAD case reports” Oral minoxidil shows promise in treating monilethrix-related hair loss.
23 citations
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January 2011 in “International Journal of Immunopathology and Pharmacology” Minoxidil 2% effectively treats Monilethrix without side effects.
97 citations
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March 2006 in “Journal of Investigative Dermatology” Mutations in the DSG4 gene cause a severe form of brittle hair and skin issues.
9 citations
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January 2001 in “Dermatology” Pili anulati may cause hair loss, proper diagnosis and treatment needed.
13 citations
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January 1991 in “Dermatology” Minoxidil helps hair growth in people with monilethrix without side effects.
40 citations
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July 2017 in “Frontiers in Medicine” Early and personalized treatment for hair loss in young people is crucial to prevent permanent damage and should include psychological support.
November 2019 in “Harper's Textbook of Pediatric Dermatology” Understanding normal hair growth and loss in children is key to diagnosing and treating hair disorders.
4 citations
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July 2022 in “Clinical and Experimental Dermatology” Using more than 5% minoxidil can help hair growth more, but results vary and side effects may increase.
6 citations
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June 2021 in “EClinicalMedicine” ALRV5XR significantly improves hair density in women with hair loss and is well-tolerated.
Afro-textured hair is more fragile and prone to certain scalp conditions, requiring careful treatment and more research for effective management.
