On the Horizon From the ORS: Platelet-Rich Plasma and Bone Health Studies

In 2010, the use of platelet-rich plasma (PRP) was investigated for various treatments, including hair restoration. PRP, rich in platelets, growth factors, and cytokines, was thought to enhance connective tissue healing. However, clinical studies showed inconsistent results, with some showing benefits in treating tendinopathy and improving postoperative outcomes in rotator cuff surgery, while others showed no significant benefit. The inconsistency was attributed to variability in PRP preparations and biological variation among individuals. The document also discussed studies on bone health in postmenopausal women, with findings showing differing effects of bisphosphonate treatment on cortical tissue heterogeneity and potential complications of alendronate therapy. The role of the periosteum in healing stress fractures was also discussed. The document concluded that future studies should examine not only which PRP product was used but also how it was used to determine the role PRP may play in the augmentation of connective tissue healing.