Polymorphisms of OCT1 and Metformin Effects in Iraqi Women with Polycystic Ovary Syndrome in Karbala City

January 2024 in “ International Journal of Biochemistry and Molecular Biology ”

Ali Hakem Kadhem

OCT1 polymorphisms metformin polycystic ovary syndrome FSH prolactin testosterone PCOS

Studysummary This study found that Iraqi women with PCOS who carry the reference wild type alleles of OCT1 had a significant hormonal and metabolic response to metformin, unlike those with mutant alleles.

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The study investigates the relationship between OCT1 polymorphisms and the effects of metformin in Iraqi women with polycystic ovary syndrome (PCOS) in Karbala city. It suggests that hormonal levels of FSH, prolactin, and testosterone could serve as potential biomarkers for detecting PCOS and predicting the biomedical response to metformin treatment. This implies that monitoring these hormone levels could enhance the management and treatment outcomes for women with PCOS undergoing metformin therapy.

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Research cited in this study

2 / 2 results

research Cutaneous Manifestations of Polycystic Ovary Syndrome

5 citations , March 2020 in “Current Opinion in Endocrine and Metabolic Research”

This review discusses the contribution of non-androgen causes to acne and female pattern hair loss in PCOS and emphasizes the need for targeted treatment approaches without relying on hyperandrogenism as a diagnostic marker.

research Polycystic Ovarian Syndrome: Correlation Between Hyperandrogenism, Insulin Resistance, and Obesity

195 citations , November 2019 in “Clinica Chimica Acta”

This review discusses the interplay of hyperandrogenism, insulin resistance, obesity, and their role in polycystic ovary syndrome, but presents no new clinical results.