Epithelial Loss of Mitochondrial Oxidative Phosphorylation Leads to Disturbed Enamel and Impaired Dentin Matrix Formation in Postnatal Developed Mouse Incisor

December 2020 in “ Scientific reports ”

Thomas Imhof, Katharina Rosenblatt, Galyna Pryymachuk, Daniela Weiland, Nicolas Noetzel, James Deschner, Olivier Baris, Sammy Kimoloi, Manuel Koch, Rudolf J. Wiesner, Yueksel Korkmaz

mitochondrial DNA oxidative phosphorylation Keratin 14 epithelial cells enamel matrix dentin matrix ameloblasts odontoblasts amelogenin Ca2+ homeostasis biomineralization ectomesenchymal cells

Studysummary This study found that mitochondrial oxidative phosphorylation in epithelial cells is necessary for proper enamel formation and odontoblast differentiation in developing incisor teeth in K320E-Twinkle Epi mice.

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