News in Brief

July 1997 in “ The Lancet ”

finasteride androgenic alopecia male-pattern baldness DHT non-vellus hairs placebo decreased libido erectile dysfunction Propecia

TLDR A new protein linked to Alzheimer's was discovered, and a hair loss treatment showed effectiveness but had some sexual side effects.

In a study of Alzheimer's disease (AD), a new protein, AMY117, was identified by John Trojanowski's team at the University of Pennsylvania's Alzheimer's Disease Center. This protein was found to be abundant and highly specific to AD, present in the brains of individuals with AD and Down's syndrome, but rare or absent in controls and other neurodegenerative diseases. This discovery could lead to new diagnostic markers and therapeutic targets for AD. In a separate study, Keith Kaufman from Merck Research Laboratories reported that oral finasteride showed promising results in treating male-pattern baldness. In phase III trials involving 1,879 men aged 18-41 with androgenic alopecia, finasteride treatment resulted in an average increase of 14.0 non-vellus hairs per cm² over 12 months, compared to a decrease of 2.3 hairs per cm² in the placebo group. However, a small percentage of treated men experienced decreased libido and erectile dysfunction.

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Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

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There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

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Hair follicles can be dormant and potentially revived with treatments like finasteride and minoxidil, but irreversible loss occurs if certain structures are destroyed. Early intervention is more effective, and additional methods like microneedling may help.

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Hair loss treatments discussed include minoxidil, finasteride, and RU58841. Salon products and supplements generally don't work for hair regrowth unless there's a severe nutritional deficiency, while hormonal treatments like estrogen and spironolactone can be effective.

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