New Complex Mechanisms in Hair Growth Regulation: Focus on Outer Root Sheath Keratinocytes

November 2019

Erika Lisztes

outer root sheath keratinocytes adenosine caffeine hair follicles telogen phase anagen phase male-pattern hair loss hair growth hair cycle

TLDR Adenosine and caffeine can promote hair growth.

The document explored the roles of adenosine and caffeine in regulating hair growth, focusing on their effects on human hair follicles (HF) and outer root sheath (ORS) keratinocytes. Adenosine, known for its physiological functions like angiogenesis and vasodilation, was previously noted for enhancing hair shaft elongation and thickening. However, questions remained about its influence on other HF cells and compartments. Caffeine, a widely-used alkaloid, was highlighted for its ability to help hair follicles transition from the telogen to the anagen phase, particularly in male pattern hair loss cases linked to high testosterone levels. The study aimed to provide deeper insights into the mechanisms by which these compounds affect the hair cycle.

View this study on hdl.handle.net →

Discuss this study in the Community →

Related Community Posts Join

6 / 61 results

community 30-Min Dermatology Visit – Best Questions to Ask About Balding? ( 175$ )

in Treatment 6 upvotes 9 months ago

The conversation discusses hair loss treatments, focusing on finasteride, minoxidil, and other options like PRP and ketoconazole. It highlights the importance of asking specific questions during a dermatology visit to determine the cause of hair loss and appropriate treatments.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 103 upvotes 3 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In)

in Research 461 upvotes 6 months ago

Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community You may not have the enzyme for topical minoxidil to work - a rarely talked about impact

in Minoxidil 100 upvotes 2 months ago

Some people may not respond to topical minoxidil due to low SULT1A1 enzyme activity, but oral minoxidil can be effective. Tretinoin may enhance minoxidil's effectiveness, and some users prefer oral minoxidil despite side effects.

community IGFBP‐rP1 is a potential therapeutic target in androgenic alopecia

in Research/Science 13 upvotes 1 year ago

IGFBP‐rP1 shows potential for treating androgenic alopecia by influencing hair cycle transitions. Increasing IGF-1 levels may have similar effects to Minoxidil and 5-AR inhibitors in reducing hair loss.