TLDR Nevoid basal cell carcinomas start in the skin's top layer and hair follicles.
The study on nevoid basal cell carcinoma syndrome revealed that these carcinomas originated in the epidermis and the upper part of the hair follicle. The early stages of these tumors were similar to nonnevoid basal cell carcinomas. The pits observed on the hands were thought to represent a localized delay in the maturation of basal cells. Additionally, the study described the histologic features of an epithelial cyst from the palm, ectopic calcium deposition in the skin, and provided electron microscopic views of the tumor cell masses.
7 citations
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February 2022 in “Stem cell reviews and reports” Skin cells show flexibility in healing wounds and forming tumors, with potential for treating hair disorders and chronic ulcers.
15 citations
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October 2014 in “Journal of Investigative Dermatology” New treatments targeting the Hedgehog pathway can help treat advanced skin cancer but may have side effects and their effectiveness in early stages is unknown.
64 citations
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March 2004 in “Journal of Clinical Investigation” Targeting ornithine decarboxylase can help prevent skin cancer.
65 citations
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March 2004 in “Journal of Clinical Investigation” Inhibiting ornithine decarboxylase may help prevent certain skin cancers.
15 citations
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July 2024 in “Current Issues in Molecular Biology” Understanding molecular processes in skin development is key to creating targeted treatments for skin disorders.
16 citations
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December 2006 in “Expert Review of Dermatology” Hair follicles are essential for skin health, aiding in hair growth, wound healing, and immune function.
