Nevoid Basal Cell Carcinoma Syndrome: Histologic Observations on Cutaneous Lesions

The study on nevoid basal cell carcinoma syndrome revealed that these carcinomas originated in the epidermis and the upper part of the hair follicle. The early stages of these tumors were similar to nonnevoid basal cell carcinomas. The pits observed on the hands were thought to represent a localized delay in the maturation of basal cells. Additionally, the study described the histologic features of an epithelial cyst from the palm, ectopic calcium deposition in the skin, and provided electron microscopic views of the tumor cell masses.