Nevoid Basal Cell Carcinoma Syndrome: Histologic Observations on Cutaneous Lesions

    March 1966 in “ Archives of Dermatology
    H. S. Zackheim
    Studysummary This study found that nevoid basal cell carcinomas originate in the epidermis and the upper part of the hair follicle, showing similarities to nonnevoid basal cell carcinomas.
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    The study on nevoid basal cell carcinoma syndrome revealed that these carcinomas originated in the epidermis and the upper part of the hair follicle. The early stages of these tumors were similar to nonnevoid basal cell carcinomas. The pits observed on the hands were thought to represent a localized delay in the maturation of basal cells. Additionally, the study described the histologic features of an epithelial cyst from the palm, ectopic calcium deposition in the skin, and provided electron microscopic views of the tumor cell masses.
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