Oxidative Stress And Hormone-Regulated Dermal Papilla Cell-Targeted Nanomodulators: Reverse Cellular Senescence For Androgenetic Alopecia Therapy

February 2026 in “ Biomaterials Research ”

Lan Lan, Qingde Zhou, Shuangxue Pan, Hui Liu, Yongzhong Du, Cuiping Guan, Ping Wang, Wei Wang

oxidative stress hormone regulation dermal papilla cells androgenetic alopecia cellular senescence nanomodulators AGA DPCs

TLDR Targeted nanomodulators can rejuvenate cells and promote hair growth in androgenetic alopecia.

The study explores the role of oxidative stress and hormone regulation in dermal papilla cells (DPCs) and their impact on androgenetic alopecia (AGA). Researchers developed nanomodulators targeting DPCs to reverse cellular senescence, a key factor in AGA progression. The study highlights the potential of these nanomodulators to rejuvenate DPCs, thereby promoting hair growth and offering a promising therapeutic approach for AGA. The findings suggest that addressing oxidative stress and hormone regulation at the cellular level can effectively combat hair loss associated with AGA.

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