Murine Epidermal Ceramide Synthase 4 Is a Key Regulator of Skin Barrier Homeostasis

February 2020 in “ Journal of Investigative Dermatology ”

Franziska Peters, Frederik Tellkamp, Susanne Brodesser, E. Wachsmuth, Bettina Tosetti, Ulrike Karow, Wilhelm Bloch, Olaf Utermöhlen, Martin Krönke, Carien M. Niessen

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Research cited in this study

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research Ceramide Synthase 4 Regulates Stem Cell Homeostasis And Hair Follicle Cycling

53 citations , February 2015 in “Journal of Investigative Dermatology”

Ceramide Synthase 4 is essential for normal hair growth and preventing hair loss.

research Ceramide Synthase 4 Deficiency in Mice Causes Lipid Alterations in Sebum and Results in Alopecia

67 citations , April 2014 in “Biochemical Journal”

Ceramide synthase 4 deficiency in mice leads to hair loss due to altered sebum lipids.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

1010 citations , August 2000 in “Cell”

Hair follicle stem cells can form both hair follicles and skin.