Muir-Torre Syndrome in Two Families in Leicestershire, United Kingdom

The document discussed two cases of Muir-Torre syndrome (MTS) in unrelated families in Leicestershire, UK. MTS is a rare genetic condition characterized by sebaceous tumors and internal malignancies, linked to DNA mismatch repair gene mutations. The first case involved a 46-year-old man with a family history of cancer and a defect in the MSH2 gene. The second case was a 51-year-old man with multiple sebaceous adenomas and a history of duodenal and colorectal cancer. Both cases highlighted the importance of recognizing minor skin lesions as indicators of serious cancer syndromes, emphasizing the need for genetic counseling and regular follow-up for patients and their families.