Modulating the Antioxidant Response for Better Oxidative Stress-Inducing Therapies: How to Take Advantage of Two Sides of the Same Medal?

The document reviewed the role of oxidative stress-inducing therapies, which involve the production of reactive oxygen and nitrogen species (RONS), in treating diseases like neurodegenerative disorders, heart disease, cancer, and others. It emphasized the importance of the body's antioxidant defense system in maintaining redox balance, which is crucial for processes like cell proliferation and regulation of cell death. By understanding the mechanisms of endogenous antioxidant systems, the therapeutic efficacy of these therapies could be enhanced, potentially leading to better clinical outcomes. The review highlighted recent findings on cellular antioxidant responses and their implications in diseases such as ulcers, skin pathologies, oncology, and viral infections, including SARS-CoV-2.