Modern Strategies for the Prevention and Treatment of Post-Burn Scars: A Systematic Review

July 2025 in “ Russian Journal of Transplantology and Artificial Organs ”

A.S. Umnikov, И.И. Глазко, Evgenii I. Balakin, А. S. Samoylov, V. I. Pustovoit

platelet-rich plasma stem cell therapy negative pressure wound therapy bone marrow-derived cells keratinocytes adipose-derived stem cells hydrogels scar hyperplasia hypertrophic scars keloid scars PRP NPWT

TLDR Combining surgical and nonsurgical methods is key to reducing post-burn scars.

Preventing and treating post-burn scars remains challenging despite advances in reconstructive surgery. A combination of surgical and nonsurgical methods, such as platelet-rich plasma injections, stem cell therapy, and negative pressure wound therapy (NPWT), is essential for improving functionality and minimizing scar recurrence. NPWT is particularly effective in preparing wound beds and preventing inflammation. The role of bone marrow-derived cells and keratinocytes in scar formation is being studied, with adipose-derived stem cells and hydrogels showing promise in promoting healing and reducing scar hyperplasia. Early surgical intervention and modern treatments can significantly lower the risk of hypertrophic and keloid scars.

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