Modern Strategies for the Prevention and Treatment of Post-Burn Scars: A Systematic Review

    July 2025 in “ Russian Journal of Transplantology and Artificial Organs ”
    A.S. Umnikov, И.И. Глазко, Evgenii I. Balakin, А. S. Samoylov, V. I. Pustovoit
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    Studysummary This research highlights advancements in reconstructive surgery for managing scars, emphasizing the importance of combined surgical and nonsurgical interventions like platelet-rich plasma and stem cell therapy to prevent and treat thick scar tissue while enhancing functionality and aesthetic outcomes.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    Preventing and treating post-burn scars remains challenging despite advances in reconstructive surgery. A combination of surgical and nonsurgical methods, such as platelet-rich plasma injections, stem cell therapy, and negative pressure wound therapy (NPWT), is essential for improving functionality and minimizing scar recurrence. NPWT is particularly effective in preparing wound beds and preventing inflammation. The role of bone marrow-derived cells and keratinocytes in scar formation is being studied, with adipose-derived stem cells and hydrogels showing promise in promoting healing and reducing scar hyperplasia. Early surgical intervention and modern treatments can significantly lower the risk of hypertrophic and keloid scars.
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