91 citations
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May 2023 in “Journal of Cutaneous Medicine and Surgery” The updated review on Alopecia Areata (AA) for 2023 provides a comprehensive overview of the condition, affecting up to 2% of the global population, and its treatment options. It highlights the role of immune dysregulation, genetic predisposition, and environmental triggers in AA's pathogenesis. Various treatments are discussed, including essential oils, garlic, glycyrrhizin, and micronutrient supplementation, with varying efficacy. Contact immunotherapy and corticosteroids are widely used, while JAK inhibitors like baricitinib show promise, with FDA approval for severe AA. The review underscores the need for more research to optimize treatment strategies, noting that severity at initial consultation is a key prognostic factor.
11 citations
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January 2022 in “Journal der Deutschen Dermatologischen Gesellschaft” Alopecia areata is a chronic condition causing hair loss, with new treatments targeting the immune system showing promise.
290 citations
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August 2021 in “Clinical Reviews in Allergy & Immunology” JAK inhibitors show promise for treating alopecia areata, but more research is needed.
55 citations
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October 2019 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” The review suggests that other immune cells besides CD8+ T cells may contribute to alopecia areata and that targeting regulatory cell defects could improve treatment.
34 citations
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October 2017 in “Archivos Argentinos De Pediatria” Alopecia Areata is a complex, unpredictable autoimmune hair loss condition with limited treatment options and a significant psychological impact.
45 citations
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December 2014 in “Journal of the European Academy of Dermatology and Venereology” Plasmacytoid dendritic cells are a key factor in causing hair loss in alopecia areata and could help differentiate it from other hair loss conditions.
701 citations
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August 2014 in “Nature medicine” Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.
218 citations
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April 2012 in “British Journal of Dermatology” Guidelines suggest various treatments for alopecia areata, but leaving it untreated is also an option as 80% cases may recover on their own.
10 citations
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February 2011 in “Journal der Deutschen Dermatologischen Gesellschaft” The document concludes that proper diagnosis and evidence-based treatments are crucial for managing hair diseases, and psychological support for patients is important.
132 citations
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November 1998 in “Journal of the American Academy of Dermatology” Topical sensitizers have mixed success in treating alopecia areata.
26 citations
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June 1988 in “PubMed” 3% topical minoxidil is ineffective for severe chronic alopecia areata.