Mitotic Activity in the Epidermis of the Rabbit Stimulated with Local Applications of Testosterone Propionate

    April 1949 in “ The journal of experimental zoology ”
    William Montagna, Patricia Kenyon, James B. Hamilton
    Image of study
    TLDR Testosterone applied to rabbit skin increases skin cell growth and changes skin structure.
    The study applied testosterone propionate topically to the ears of four adult rabbits and found that it significantly increased the thickness of the epidermis and stimulated mitotic activity, especially in the basal cells and the lower layers of the stratum spinosum. The treatment also led to the formation of long epidermal papillae and cords, some with sebaceous differentiation, and increased dermal vascularity. The results indicate that the adult epidermis can undergo sebaceous differentiation and that androgenic stimulation can enhance the metabolic activities of the skin and its appendages. The document also includes detailed observations of the stages of mitosis in the treated epidermis, highlighting the increased mitotic activity and the orientation of mitotic axes in response to androgen stimulation.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Why is no one pointing out dandruff as the number 1 evidence/symptom of MPB?

      in Chat  55 upvotes 1 year ago
      The post discusses the theory that persistent dandruff in areas prone to hair loss could be a sign of hair follicles dying due to DHT, indicating balding. The responses vary, with some users noting improvements in dandruff and hair loss with treatments like Dutasteride, while others experienced hair loss without dandruff.

      community I am having Success with RU58841 and 1mm Derma Roller

      in Microneedling  19 upvotes 2 years ago
      A user reported success with RU58841 and a 1mm derma roller for hair regrowth, noting significant improvement in hair density and reduced scalp visibility. They also mentioned using minoxidil and black castor oil in the past, with mixed results.

      community How to know if shedding is from tren or minoxidil?

      in Minoxidil  5 upvotes 7 months ago
      The user started using trenbolone and minoxidil simultaneously and experienced increased hair shedding, unsure which is causing it. Replies suggest both drugs could cause hair loss, with one advising to stop trenbolone to protect hair and another indicating minoxidil is unlikely the cause due to the timing.

      community Is this broscience? From More Plates, More Dates

      in Research/Science  22 upvotes 8 months ago
      The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

      community any news about DUPA (Diffuse unpatterned alopecia)?

      in Research/Science  11 upvotes 1 year ago
      The conversation discusses diffuse unpatterned alopecia (DUPA) and its possible causes, including sensitivity to DHT, not being androgenic alopecia, being diffuse alopecia areata, or hormonal issues. Treatments mentioned include topical melatonin, Clobetasol Propionate for alopecia areata, and the lack of results from using finasteride, dutasteride, and minoxidil.

      community Just find a cure already, I am totally done

      in Chat  161 upvotes 2 months ago
      The conversation is about hair loss treatments, with users recommending finasteride and minoxidil as effective solutions. Some users report side effects, but overall, the consensus is to use these treatments rather than waiting for a cure.

    Similar Research

    5 / 1000+ results