TLDR The new wound dressing with minoxidil and dexamethasone could speed up healing and reduce scarring in rats.
The study aimed to develop a nanofiber dressing that elutes minoxidil and dexamethasone for wound healing in rats. Minoxidil is known to promote blood flow, which may speed up wound closure, while corticosteroids like dexamethasone can down-regulate healing. The developed dressings were characterized using SEM and FT-IR, and drug release was studied over 12 days. In the rat model, wounds treated with minoxidil showed good healing activity, likely due to the promotion of anagen hair growth phase, while dexamethasone was found to suppress collagen production and prevent scar formation. The study concludes that the minoxidil and dexamethasone-eluting wound dressing has the potential to be a new clinical treatment to accelerate wound healing and prevent scarring.
Cited in this study
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6 citations
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August 2014 in “Spectroscopy Letters” The analysis shows where minoxidil's atoms are likely to react and describes its electronic transitions and behavior with temperature changes.
26 citations
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August 2013 in “Pharmaceutical Development and Technology” PEVs effectively deliver minoxidil through skin.
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8 citations
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5 citations
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1 citations
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January 2010 Mesotherapy is more effective than topical spray for female hair loss treatment.
269 citations
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39 citations
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March 1987 in “Journal of The American Academy of Dermatology” Topical minoxidil is a safe and effective treatment for hair loss caused by androgenetic alopecia.
20 citations
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80 citations
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