Approach to Meta-Analyses of Multiple Treatment Comparisons: A Literature Review

The document reviewed multiple treatment comparison meta-analyses, which are systematic reviews enabling direct or indirect comparisons of various interventions using data from randomized clinical trials. These analyses, also known as network or mixed treatment comparison meta-analyses, provided a quantitative expression of outcomes, enhancing the estimation of intervention effects. The review aimed to guide physicians in making informed decisions and improving patient care by offering a structured approach to critically reading these analyses, following JAMA recommendations. It targeted authors and editors, providing insights on interpreting and communicating such studies.