Beneficial Effects of Melatonin on Changes in Acute Necrotizing Pancreatitis Ultrastructure in Rats

The study aimed to evaluate the effects of melatonin on intestinal epithelial cells in rats with acute necrotizing pancreatitis (ANP). Seventy-two rats were divided into three groups: sham operation, ANP, and ANP with melatonin treatment. The ANP model was induced using sodium taurocholate, and melatonin was administered before the operation. Results showed that ANP led to significant necrosis and apoptosis in intestinal epithelial cells, with notable ultrastructural abnormalities. Melatonin treatment reduced these pathological changes and apoptosis, suggesting its potential protective role through anti-oxidation and inhibition of inflammatory responses. Further research was recommended to explore these mechanisms.