Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFkB and AP-1
February 2023
in “International Journal of Molecular Sciences”
TLDR Melatonin improves cashmere goat hair quality by increasing follicles and reducing skin aging.
The study, involving 15 goats in each of the 6 age groups (2, 3, 4, 5, 6, 7 years) for both the melatonin-treated and untreated control groups, found that melatonin (MT) improved the quality and yield of cashmere fibers in adult cashmere goats, particularly in those over 5 years old. This was achieved by increasing the number of secondary hair follicles, reducing oxidative stress, and regulating the Keap1-Nrf2 pathway. MT also reduced the expression of the inflammatory transcription factors NFκB and AP-1 and lowered levels of the SASP cytokines, which delayed skin aging and improved the microenvironment of secondary hair follicles.
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