TLDR The skin lesion was diagnosed as a matrical cyst with unusual features.
A skin lesion from a 10-year-old Samoyed dog was examined and diagnosed as a matrical cyst, despite not fitting perfectly into any known categories of follicular cysts or neoplasms. The lesion was a unilocular cyst with unusual features, including large squamous-like cells and an abundance of ghost cells. Differential diagnoses considered included acantholytic squamous cell carcinoma, tricholemmal cyst, and pilomatricoma, but these were excluded based on specific histopathological characteristics. The matrical cyst diagnosis was made due to the presence of large squamous cells, although this differed from the typical basaloid cell type usually associated with such cysts.
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