Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin
July 2014
in “Cold Spring Harbor Perspectives in Medicine”
TLDR The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.
The document from 2014 reviews the identification and characterization of epidermal stem cell subpopulations in adult mammalian skin, particularly focusing on murine and human models. It outlines the use of various techniques such as label retention, clonogenic assays, skin reconstitution, and genetic lineage tracing to study these cells. Key findings include the presence of multiple stem cell populations beyond the traditionally recognized bulge area of hair follicles, with markers such as CD34, K15, and SOX-9 being significant for hair follicle stem cells. The document also notes the creation of a new transgenic mouse line for better tracking of bulge stem cell progeny and discusses the challenges in characterizing human hair follicle stem cell markers, which has implications for understanding hair regeneration defects like androgenetic alopecia. Additionally, it highlights the plasticity of epidermal stem cells and their regulation, which is crucial for skin homeostasis, regeneration, and responses to conditions such as cancer, baldness, and aging. However, the behavior of these cells in such skin changes is not fully understood.
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