Low Temperature and MTOR Inhibition Favor Human Epidermal Stem Cell Maintenance

April 2023 in “ Journal of Investigative Dermatology ”

J. Sakabe, D. Nanba, J. Mosig, M. Brouard, F. Toki, M. Shimokawa, M. Kamiya, T. Braschler, F. Azzabi, S. Droz-Georget Lathion, K. Johnsson, K. Roy, C.D. Schmid, J. Bureau, A. Rochat, Y. Barrandon

Studysummary This study found that human epidermal stem cells can adapt to small temperature variations via mTOR signaling, and that prolonged mTORC1 inhibition supports stem cell maintenance.

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