Low-Level Laser Therapy in Immune-Mediated Skin Disease: A Narrative Review

Low-level laser therapy (LLLT) is being investigated as a treatment for immune-mediated skin diseases like alopecia areata (AA), psoriasis, and atopic dermatitis. It works by stimulating mitochondrial activity, which can lead to tissue regeneration, reduced inflammation, and pain relief. Studies have shown promising results for AA, with one study reporting hair regrowth in 32 out of 34 patches, and another indicating 46.7% of patients had earlier hair regrowth in treated areas. However, the effectiveness of LLLT for psoriasis is unclear, with mixed results from different studies. For atopic dermatitis, LLLT may be effective but there is a risk of exacerbating Th2-mediated conditions. Despite its safety and lack of side effects, further research is needed to confirm LLLT's efficacy and to potentially extend its use to other immune-mediated diseases.