Low-Level Laser Therapy in Immune-Mediated Skin Disease: A Narrative Review

    December 2022 in “ Medical lasers ”
    Joon Seok, Young Gue Koh, Beom Joon Kim
    From the encyclopedia
    Low Level Laser Therapy →

    laser therapy for anti-inflammatory and likely insignificant hair regrowth effects

    Alopecia Areata →

    autoimmune disorder causing patchy hair loss

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    Studysummary This study reviews the mechanism and potential treatment roles of low-level laser therapy for immune-mediated skin diseases, reporting no new clinical results. Our plain-language summary of this paper — not a Tressless recommendation.
    Low-level laser therapy (LLLT) is being investigated as a treatment for immune-mediated skin diseases like alopecia areata (AA), psoriasis, and atopic dermatitis. It works by stimulating mitochondrial activity, which can lead to tissue regeneration, reduced inflammation, and pain relief. Studies have shown promising results for AA, with one study reporting hair regrowth in 32 out of 34 patches, and another indicating 46.7% of patients had earlier hair regrowth in treated areas. However, the effectiveness of LLLT for psoriasis is unclear, with mixed results from different studies. For atopic dermatitis, LLLT may be effective but there is a risk of exacerbating Th2-mediated conditions. Despite its safety and lack of side effects, further research is needed to confirm LLLT's efficacy and to potentially extend its use to other immune-mediated diseases.
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