Long-term treatment of severe hypertension with minoxidil, propranolol and furosemide.

    October 1975 in “ Circulation
    R. L. Wilburn, A H Blaufuss, C.-M. Bennet
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    TLDR Minoxidil, propranolol, and furosemide effectively control severe hypertension, but may cause sodium retention.
    The study investigated the long-term treatment of severe hypertension with minoxidil, propranolol, and furosemide. The combination of these drugs was found to be highly effective in controlling severe hypertension for up to 25 months, with no long-term toxic effects of therapy detected. However, severe sodium retention requiring large doses of furosemide to avoid increasing body weight and edema was a frequently observed factor associated with tolerance to the hypotensive effect of arteriolar dilatation.
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