Long-Term Treatment of Refractory Hypertensive Patients With Minoxidil
May 1978
in “JAMA”
TLDR Minoxidil controls blood pressure but may cause kidney damage and needs diuretics to prevent swelling.
This 45-year-old study reports on the use of minoxidil to treat refractory hypertension in patients who have not responded to other treatments. The study found that minoxidil was effective in controlling blood pressure, but some patients experienced progression of end-organ damage, particularly renal failure. The study also suggests that minoxidil may have vasodilatory activity in pulmonary arteries and does not cause pulmonary hypertension. Large doses of diuretic agents were required to prevent edema, and some patients eventually required hemodialysis.
View this study on jama.jamanetwork.com →
Cited in this study
research The effects of minoxidil on pulmonary and systemic hemodynamics in hypertensive man.
Minoxidil lowers blood pressure and increases heart efficiency, but may raise lung artery pressure in some people.
research Long-term treatment of severe hypertension with minoxidil, propranolol and furosemide.
Minoxidil, propranolol, and furosemide effectively control severe hypertension, but may cause sodium retention.
research Minoxidil in severe hypertension: Value when conventional drugs have failed
Minoxidil effectively controls blood pressure in severe cases, but may cause fluid retention and edema.
research Minoxidil — An Alternative to Nephrectomy for Refractory Hypertension
Minoxidil effectively lowers blood pressure with few side effects.
research Minoxidil in severe hypertension with renal failure
Minoxidil effectively lowers blood pressure without major side effects.
research Pharmacologic properties of minoxidil: a new hypotensive agent.
Minoxidil is a new drug that lowers blood pressure.
Related
research Long-Term Treatment of Refractory Hypertensive Patients With Minoxidil
Minoxidil controls blood pressure but may cause kidney damage and needs diuretics to prevent swelling.