Study of Long-Term 15-Day Imiquimod Treatment and Drug Intervention in Localized Psoriasiform Dermatitis Model

The study investigated the long-term effects of Imiquimod (IMQ) treatment and the impact of an anti-inflammatory drug on psoriasiform dermatitis in two mouse strains. The mice were treated with Aldara cream (5% IMQ) for 15 days, with skin samples collected on days 5, 10, and 15. The results showed that skin inflammation was most intense on day 5, after which the skin regained its normal appearance. From day 12, hair growth was observed in the Aldara-treated areas in all groups except the steroid treatment group. Skin infiltration increased until day 5, then a second peak developed from day 10 until the end of the experiment. Topical corticosteroid significantly reduced skin infiltration from day 6 and also significantly reduced inflammatory cytokines on days 10 and 15. The study concluded that the application of Aldara in Finn chambers allows for the study of long-term IMQ treatment and the investigation of topically applied anti-inflammatory drug candidates in psoriasiform dermatitis.