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This study found that applying topical imiquimod during mid and late telogen in mice activates hair follicle stem cells and influences immune cell infiltration, promoting hair cycle entry independently of Wnt signaling.

This article discusses the use of imiquimod as a treatment for actinic keratosis, basal cell carcinoma, and human papillomavirus warts, noting both its therapeutic benefits and common side effects such as local inflammation and flu-like symptoms.

In this study, Makarova et al. found that topical vitamin D3 significantly delayed basal cell carcinoma development in UVR-exposed, BCC-prone mice, while oral vitamin D3 supplements did not prevent carcinogenesis, suggesting a potential role of UV-induced vitamin D3 in inhibiting tumor growth.

In this study on mice, researchers observed that dermal white adipose tissue (dWAT) plays a key role in regulating skin inflammation and tissue repair; however, reduced expression of certain cytokines in obese mice may hinder these processes, indicating potential metabolic disruptions in dWAT during inflammation.

This study found that long-term imiquimod treatment on mice intensified skin inflammation early on, but topical corticosteroids significantly reduced skin infiltration and inflammatory cytokines after initial inflammation subsided.